CP0119 is a novel small molecule transgelin agonist. Transgelin is an actin binding protein in the calmodulin family, with a relative molecular weight of 22kDa, mainly distributed in smooth muscle cells. CP0119 can stimulate Transgelin on intestinal smooth muscle cells, promote the aggregation of G-actin to F-actin, increase the formation of stress fiber bundles in intestinal smooth muscle cells, thereby enhancing cell contraction ability, promoting intestinal peristalsis, and ultimately achieving the effect of improving chronic constipation. And currently, there are no similar drugs targeting Transgelin for the treatment of constipation on the market. The successful development of CP0119 belongs to the innovative drug class 1 with a new target.

Part of the content is quoted from: https://pharmacy.nankai.edu.cn/info/1061/2471.htm

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