pharmacokinetics study
Service items
■ LC-MS analysis of biological samples
■ Protein binding research
■ CYP450 enzyme induction test
■ CYP450 enzyme inhibition test
■ Metabolic phenotype study (RAF method)
■ Metabolic stability study
■ Tissue distribution test
■ Glutathione capture test
■ Permeability study (Caco-2 model)
■ Protein binding research
■ CYP450 enzyme induction test
■ CYP450 enzyme inhibition test
■ Metabolic phenotype study (RAF method)
■ Metabolic stability study
■ Tissue distribution test
■ Glutathione capture test
■ Permeability study (Caco-2 model)
Service advantages
> Blood collection from jugular sinus: Animals do not require anesthesia and can be used for blood sample collection in toxicokinetics and pharmacokinetic studies.
> Bile duct catheterization in conscious rats: An extracorporeal catheter was used for bile duct catheterization to collect bile samples from conscious rats.
