Pharmacodynamic screening
Service items
Pharmacodynamic studies can be used to predict the effectiveness of drugs in animals. The established models include:
■ Respiratory diseases: pulmonary fibrosis model, pulmonary embolism
■ Digestive system diseases: various gastric ulcer and duodenal ulcer, reflux esophagitis, functional constipation model, diarrhea model
■ Circulation and blood system diseases: acute and chronic heart failure, myocardial ischemia, myocardial ischemia reperfusion, myocardial infarction
■ Metabolic system diseases: diabetes model, obesity model, hypopituitarism model, clamp test
■ Neuropsychiatric diseases: cerebral ischemia model, cerebral ischemia reperfusion model
■ Immune related diseases: arthritis model
■ Tumor: subcutaneous and orthotopic tumor
■ Respiratory diseases: pulmonary fibrosis model, pulmonary embolism
■ Digestive system diseases: various gastric ulcer and duodenal ulcer, reflux esophagitis, functional constipation model, diarrhea model
■ Circulation and blood system diseases: acute and chronic heart failure, myocardial ischemia, myocardial ischemia reperfusion, myocardial infarction
■ Metabolic system diseases: diabetes model, obesity model, hypopituitarism model, clamp test
■ Neuropsychiatric diseases: cerebral ischemia model, cerebral ischemia reperfusion model
■ Immune related diseases: arthritis model
■ Tumor: subcutaneous and orthotopic tumor
Service advantages
＞Jugular sinus blood sampling technique:
The animals do not need anesthesia, with small trauma, in line with animal ethics, and can meet the requirements of PK/TK blood collection.
＞Bile duct intubation technique in conscious rats:
Bile collection in conscious rats lasting more than 72 hours can be achieved by means of bile duct intubation and external catheterization.
＞Cerebrospinal fluid collection technology:
Cerebrospinal fluid of conscious/anesthetized animals can be collected for the study of blood-brain barrier permeability.
The animals do not need anesthesia, with small trauma, in line with animal ethics, and can meet the requirements of PK/TK blood collection.
＞Bile duct intubation technique in conscious rats:
Bile collection in conscious rats lasting more than 72 hours can be achieved by means of bile duct intubation and external catheterization.
＞Cerebrospinal fluid collection technology:
Cerebrospinal fluid of conscious/anesthetized animals can be collected for the study of blood-brain barrier permeability.
