The early drug formation of compounds can be studied through toxicity prediction, pharmacokinetic screening, and efficacy screening studies, including cardiac toxicity risk prediction, tolerance dose of related species, bioavailability, cytotoxicity, and genotoxicity.

 Non GLP cardiovascular safety screening test: hERG patch clamp
 Tolerance exploration: rats, mice, dogs, monkeys
 Cytotoxicity screening study
 Genotoxicity screening study

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